You've probably already considered this, but definitely have all the details concerning work visas and licensing and every other conceivable kind of paperwork taken care of before you go, and if possible have jobs lined up already. In my family, we all went through the process to gain citizenship in Ireland (there's a legacy law there that offers citizenship to anyone who's grandparents were born there if they meet certain legal criteria.) One of my sisters moved to Ireland a few years ago and despite having citizenship, it was a nightmare for her. She's a social worker here and figured if she had citizenship and working papers, she'd have no trouble finding work. Not true. Even if you can establish yourself over there, without a guaranteed employment, it can be very difficult to get work. Priority is given to naturally born citizens every time. I'm not sure if it's the same in England, but find out and do whatever you can to make it a smooth transition before you go. In the end, my sister had to bail and come back here because her long term prospects involved living off her savings for quite a long time before she'd likely find a job. I'd imagine the job market is softer now given the pandemic, so while your wife might be able to find work in healthcare, you might face limited prospects.