serviceguy
Well-Known Member
It's been nice to know you...
Lyme Disease Thread
- Thread starter pixychick
- Start date
rick81721
Lothar
Wonder if they are running it down here? Have to check the local research facility that was running the Alzheimers drug study I entered earlier this year (but ended up not qualifying).
I wonder if getting the first Lymerix vaccine is a disqualifier? I got that one.
they asked about lymerix - so maybe.
Did you see that there is a connection between alzheimers and gingivitis ?
they just aren't sure if the gingivitis could be a cause or result....
rick81721
Lothar
Hadn't heard about it but just looked. It's not gingivitis, it's periodontal disease. Almost everyone has gingivitis to some extent. It's one of the key bacteria that cause perio - F. nucleatum, which can trigger systemic inflammation and exacerbate Alzheimers. Perio is also linked to diabetes and heart disease for the same reason.
w_b
Well-Known Member
So:
1. You don’t have Lyme.
2. Your future potential exposure to Lyme is unknown.
3. You don’t know if you got some investigational drug, or placebo, or if subject investigational drug works.
How are they supposed to draw any meaningful conclusions? Or is there something actually known in all this injecting?
1. You don’t have Lyme.
2. Your future potential exposure to Lyme is unknown.
3. You don’t know if you got some investigational drug, or placebo, or if subject investigational drug works.
How are they supposed to draw any meaningful conclusions? Or is there something actually known in all this injecting?
@rick81721 and @jmanic you are up
Double blind study with 18,000 participating.
Participants must be subject to exposure.
They did a blood draw, and asked if I had ever been diagnosed. They question if I go outside, if I had pets that go outside, and if wildlife visits my yard. And the amount of forest where I live
They will do three or four more blood draws. And I need to report any tick bite
Hey all , have been a member for years , but never really commented on stuff . Lyme's is serious and debilitating if left unchecked . I have been riding the pines for decades and brought home many a tick . The one that has got me is Alpha-Gal , which makes you allergic to beef , lamb and pork . Which really sucks , reactions can be mild or violent till you figure out the triggers . Headache , flushing , hives , itching (pits and crotch} ,to nausea and diarrhea . Sorry a little off subject , but just putting it out there .
rick81721
Lothar
That's a robust study. Same as other vaccine studies - they will compare incidence of Lyme disease in test vs placebo groups. Blood tests will identify exposure via antibodies to the Lyme bacteria.
Mahnken
Well-Known Member
Where can I sign up?
Yup @Rick8675309 beat me to it, but yeah, that’s what you got.
Basically designed just like the Covid vax (and all other vax) studies.
18k participating is to ensure precision in the estimated rates of Lyme+
More data = more precision.
Sample size would also be determined by rates of Lyme in general- something that has lower rates means you need more data points for accurate precision.
Will probably do incidence rates overall and by confirmed bites to determine if it works.
Efficacy studies precede effectiveness studies. Efficacy being ideal controlled conditions - best case scenario.
Effectiveness studies follow- real world conditions.
Given they had some exclusion criteria, this might be efficacy, can’t say for sure.
If they ask you to sleep naked in the woods, I’d probably discontinue participation, unless you’re into that sort of thing.
knobbyhead
Next off the Island.
Patrick, post: 1167634, member: 7568"]
Learned that the bullseye rash doesn't need to be at the bite site.
[/QUOTE]
I got lymes 2xs. 2nd time I never saw the bullseye's. Best defense is know the signs of lymes and get tested if you think you have it.
Learned that the bullseye rash doesn't need to be at the bite site.
[/QUOTE]
I got lymes 2xs. 2nd time I never saw the bullseye's. Best defense is know the signs of lymes and get tested if you think you have it.
JDurk
Well-Known Member
I got lymes 2xs. 2nd time I never saw the bullseye's. Best defense is know the signs of lymes and get tested if you think you have it.
[/QUOTE]
2x for me too. 1st, bullseye. 2nd no bullseye, just the same symptoms and an itchy spot I assumed was the bite location. Cycle of doxy both times had me feeling better in a few days.
My person said they are closing enrollment because they have met the requirements.
if you want to try, i'll dm you the email address.
rick81721
Lothar
Most clinicals like this are by definition efficacy. Effectiveness is usually determined post-approval post-launch by doing epidemiological studies across the population.
zmartene
Well-Known Member
Veterinarian checking in. These are the ticks that scare me most - the nymph stage. Every time someone tells me they don't need preventatives because they don't see ticks on their dog, these guys are what cross my mind. And that's actually a pretty big nymph. Tell me how you think you can see that in your husky's fur coat.... I'm lucky my patients have a great Lyme vaccine available. If your dog isn't vaccinated, call your vet tomorrow and ask why they didn't recommend it strongly enough. In this part of the country, it should be considered a core vaccine.
Mahnken
Well-Known Member
I didn't even know they had a vaccine. I'm likely switching vets anyway because we just moved. I'll ask the new place.
Mahnken
Well-Known Member
I guess I can wait. Gonna get a bunch of guinea fowl to eat all the ticks in the backyard.
