We rented a house off VRBO a few blocks east of 'Lombard Street' close to Columbus Ave. Walked mostly everywhere in that area. We did so much. Alcatrez, Fireworks, Golden Gate Bridge, Golden Gate Park, Giants game, Palace of Fine Arts, list goes on
Then we rented a house in Sunset. It was awesome. Very local thing to do and the food was great in Sunset area. Toddler loved the beach for getting her feet wet.
Ate good food everywhere we went. Don't think we had any american food.
Uber in SFO rocks.
What a neat city you can enjoy over and over.