I was planning to go to Pitt to pick up Jamie from college today but he got a ride home over the weekend.
Anyway, you drive past the State College area on the way out, this is a good opportunity to stop and ride Raystown or Rothrock. Its roughly a 6hr trek to Pittsburgh, a mtb stop is a nice way to break up the ride. I would lean toward Raystown since its easier to navigate and very fast flowey trails. From there Pittsburgh is only 2 hrs away. Pittsburgh itself has trails not far from the city worth checking out, although I never have its on my list.
Let us know how it works out.